Acutis Steps Up at the 19th Annual ASAP Conference

From September 23rd through the 27th 2018,  CEO Jibreel Sarij and Sales Specialists Jared Blais and Emily Talarico attended the Alcoholism and Substance Abuse Providers of New York State (ASAP) Annual Conference in Syracuse, New York. 

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That we’re in the midst of a crisis is not news. All attendees at the ASAP Conference are acutely aware of the enormity of the problem. Ben Walsh, the Mayor of Syracuse, mentioned in his remarks that a death by an overdose occurred only a few days earlier, a block from the conference center. Everyone, from caseworkers and administrators, to medical practitioners and specialists, had their war stories. There was no shortage of tactics and strategies discussed, all focused on ASAP’s guiding principle that addiction is a treatable and preventable disease.

A highlight of the conference was a talk by the journalist Sam Quinones, author of the National Book Critics Circle Award-winning book, Dreamland: The True Take of America’s Opiate Epidemic. Quinones took on one of the most controversial issues of the day: how heroin moved from the urban centers into our nation’s heartland.

During the event, Jibreel Sarij spoke at length with ASAP’s Executive Director John Coppola, The two discussed how the ASAP might tap into Acutis’ expertise in drug testing and also how the ASAP might benefit from access to vast amounts of data Acutis has compiled. Coppola accepted an invitation to visit our facility.

We look forward to new friends and a dynamic collaboration.

Visit the 19th Annual ASAP Conference website.

Just don’t call it weed

In early July, the U.S. Food and Drug Administration approved Epidiolex® (cannabidiol or CBD), an oral solution derived from marijuana, for the treatment of two severe pediatric seizure disorders. Epidiolex® is the first, yes, the first, FDA-approved medicine made from a purified extract of the marijuana plant—all natural and nothing synthetic.

Studies have confirmed what has been reported anecdotally about CBD oils—that they are helpful in treating seizures. But stories that circulate like rumors have always been incomplete if not disappointing. That said, starting this autumn, parents whose children suffer from Lennox-Gastaut and Dravet syndromes will have a safer and more reliable treatment than CBD products currently hawked on the Internet or sold in marijuana dispensaries.

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FDA approves first drug derived from marijuana.
July 2, 2018

Last week, the Food and Drug Administration(FDA) approved Epidiolex® (cannabidiol, or CBD), a medication extracted from marijuana, for the treatment of two severe pediatric seizure disorders, Lennox-Gastaut syndrome and Dravet syndrome. CBD is a compound typically found in very small quantities in the marijuana plant, and it has been of interest to scientists and the public for several years due to its anti-seizure properties and other possible therapeutic benefits. The approval comes at the end of a four-year series of trials showing the benefits of CBD in relieving the symptoms of these seizure disorders, which are highly resistant to existing treatments.

Lennox-Gastaut and Dravet syndromes are extremely debilitating. Children often suffer multiple seizures per day, they are likely to have developmental problems and are at high risk for early mortality. For several years, desperate parents with children suffering from these disorders sometimes relocated to states where marijuana had been legalized to obtain CBD oils, since this compound had been reported anecdotally to be helpful.

Read the full article online on the National Institute on Drug Abuse (NIDA) website.

Surprising and disturbing

Best business practices require a familiarity with current news. Toward that end, we read industry white papers and university studies, as well as national and local news stories. But familiarity is our point of departure.

News that finds its way into our laboratory will often find its way into our strategies and eventually into new services. Where this particular story leads we can’t say, but as we found it as surprising as it is disturbing, we believe it is worth publishing here.

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Mussels in Washington's Puget Sound test positive for opioids, other drugs

“Shellfish in the Puget Sound, an inlet of the Pacific Ocean along the northwest coast of Washington, tested positive for the prescription opioid oxycodone... The mussels also contained four kinds of synthetic surfactants -- the chemicals found in detergents and cleaning products -- seven kinds of antibiotics, five types of antidepressants, more than one anti-diabetic drug and one chemotherapy agent.”

“Scientists have not studied whether mussels are harmed by oxycodone. However, the presence of this drug in the mollusk speaks to the high number of people in the urban areas surrounding the Puget Sound who take this medication, said Lanksbury.”

"We decided it was important for us to start looking for 'contaminants of emerging concern,' " she said. This term refers to pharmaceuticals and personal care products -- including prescription drugs, detergents, shampoos and micro-plastic beads -- that are increasingly being detected in waterways, such as the Puget Sound.

A study conducted by the US Geological Survey found measurable amounts of one or more medications in 80% of the water samples drawn from 139 streams in 30 states.”

Follow this and related stories:

Expectations met at ICCO 2018

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Acutis Diagnostics’ Charlie Clark and Chuck Orefice attended the International Conference on Opioids, at the Joseph B. Martin Conference Center at Harvard Medical School in Boston, Massachusetts, held from June 10th - 12th, 2018.

We came with high expectations for this meeting, especially in light of the current crisis. We were not disappointed. Thought leaders and practitioners from the U.S. and abroad addressed topics of increasing urgency, from the best emerging medical practices using opioid to treat pain, to the rapidly evolving ethical and legal aspects of opioid management.

Acutis Diagnostics is intimately familiar with the challenges faced by physicians who seek greater clarity and new competences. Toward that end, we were excited to learn new concepts and applications in medication monitoring and illicit drug testing. We will continue to hone our science and services with a single goal in mind: reduce risk to both practitioners and patients, while improving clinical outcomes.

Fentanyl-laced heroin overdoses rise California signaling higher need for clinical caution

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The CDC reports that opioids of all types have killed more than 33,000 people in 2015 alone, and the number is rising. A newer threat of mixed opioids plagues Ventura County in California and could signal a need for more caution across the country.

Ventura County has reported a rise in fatal opioid overdoses that could be attributed to the spread of heroin laced with fentanyl. “People are using these drugs expecting one result and getting a much more potent result, a result that can end up with death,” says Dr. Robert Levin, a physician and public health officer in the county. The public health officials of the county note that opiates can be accessed very easily, sometimes by mail order, and that there is very little oversight in the mixes of opioids that people are purchasing illegally.

Some forms of synthetic opioids are significantly easier to produce and sell illegally than are others. Carfentanyl and fentanyl are both extremely potent in small quantities and present an extreme health risk as a result. Synthetic opioids as a whole have caused 72.2% more deaths from 2014 to 2015, according to the CDC. The CDC also reports that the rates at which confiscated drugs testing positive for fentanyl are growing faster than prescription rates. This indicates that synthetic opioids like fentanyl are further infiltrating the street and illicit drug use scene.

It is the mixing of synthetic opioids with heroin that is most troubling, especially for Ventura County. Fentanyl is a synthetic opioid that is 50 to 100 times more potent than morphine. Heroin, in comparison, is two to four times as potent as morphine, according to a research article in the Journal of Pharmacology and Experimental Therapeutics. Mixing fentanyl and heroin can easily produce an opioid dose that exceeds the potency of safely prescribed amounts of opioids by several orders of magnitude.

What can be done about this problem?

Ultimately, opioid dependence and addiction must be resolved under supervision of a qualified health provider. A core component of any addiction or dependence treatment program is toxicology-based monitoring for compliance and for metrics. Acutis Diagnostics is a New York toxicology lab that works closely with the medical and patient community to ensure safe, healthy, and timely treatment of all disorders, including opioid dependence and addiction. Please contact Acutis Diagnostics to learn how the services offered here can help provide a path to treatment for all patients.

For more information about the recent events in Ventura County, please look at this article by the Ventura County Star.

For more information about fentanyl and to see a wealth of information about the opioid crisis, visit the CDC’s page about fentanyl here.

To read the Journal of Pharmacology and Experimental Therapeutics’ article about equivalent doses of heroin and morphine, please click here.

This article is written by Yusuf Sheth. Yusuf is a Masters of Public Health Candidate at Downstate Medical Center.

Marijuana wins big on election night

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Voters in California, Massachusetts and Nevada approved recreational marijuana initiatives Tuesday night, and several other states passed medical marijuana provisions, in what is turning out to be the biggest electoral victory for marijuana reform since 2012, when Colorado and Washington first approved the drug's recreational use.

In addition to the states above, local outlets in Maine are declaring victory for that state's legalization measure, but with 91 percent of precincts reporting just a few thousand votes separate the "Yes" and "No" columns.

A similar legalization measure in Arizona did not gain sufficient support to pass, with 52 percent of voters rejecting it.

On the medical side, voters in Florida, North Dakota and Arkansas have approved medical marijuana initiatives. Voters in in Montana also rolled back restrictions on an existing medical pot law.

Reformers were jubilant. “This represents a monumental victory for the marijuana reform movement,” said Ethan Nadelmann, executive director of the Drug Policy Alliance, in a statement. “With California’s leadership now, the end of marijuana prohibition nationally, and even internationally, is fast approaching.”

California has long been seen as a bellwether by both supporters and opponents of marijuana reform. The state is home to about 12 percent of the U.S. population. Given the size of the state's economy and the economic impact of the marijuana industry there, California's adoption of legal marijuana could prompt federal authorities to rethink their decades-long prohibition on the use of marijuana.

In a recent interview with Bill Maher, President Obama said that passage of the legalization measures on Tuesday could make the current federal approach to the drug “untenable.”

Still, the likelihood of a Trump White House leaves a lot of uncertainty about the fate of marijuana measures in the next four years. Under Obama, federal authorities largely took a hands-off approach to state-level legalization efforts. But an incoming administration more skeptical of drug reform could easily reverse that approach.

“The prospect of Rudy Giuliani or Chris Christie as attorney general does not bode well,” the Drug Policy Alliance's Nadelmann said in an interview. “There are various ways in which a hostile White House could trip things up.”

Nadelmann pointed to the success of marijuana measures in the midst of an evident Republican wave as a sign that support for legalization now cuts deeply across party lines. And citing Trump's often contradictory statements on marijuana and drug use in the past, Nadelmann added that “Donald Trump personally could probably go any which way on this.”

With today's votes, legal marijuana is also making significant inroads in the Northeast. “Marijuana legalization has arrived on the East Coast,” said Tom Angell of the marijuana reform group Marijuana Majority in an email. “What Colorado and other states have already done is generating revenue, creating jobs and reducing crime, so it’s not surprising that voters in more places are eager to end prohibition.”

Opponents of legalization said they were disappointed by the outcomes. “We were outspent greatly in both California and Massachusetts, so this loss is disappointing, but not wholly unexpected,” said Kevin Sabet of the anti-legalization group Smart Approaches to Marijuana in a statement. “Despite having gained considerable ground in the last few weeks, the out-of-state interests determined to make money off of legalization put in too much money to overcome.”

Votes on medical marijuana in Florida and North Dakota were decisive. Florida's Amendment 2 passed with 71 percent support, according to the Associated Press. In North Dakota, the AP reportsthat 64 percent of voters approving of the medical marijuana measure.

Two years ago, a medical marijuana measure in Florida earned 58 percent of the vote, just shy of the 60 percent threshold needed for passage. Then, as now, opposition to the measure was fueled by multimillion-dollar donations from Sheldon Adelson, the Las Vegas casino magnate and GOP donor. In 2014 Adelson spent $5.5 million to defeat the measure. This year he's spent $1.5 million in Florida, and several million more to defeat recreational marijuana measures in other states.

“This is a major tipping point,” said Tom Angell of Florida's vote. “With Florida's decision, a majority of states in the U.S. now have laws allowing patients to find relief with medical marijuana, and these protections and programs are no longer concentrated in certain regions of the country like the West and Northeast.”

The victory in North Dakota is something of a surprise as no polling was done on the measure.

The Florida amendment has the potential to be one of the more permissive medical marijuana regimes in the nation. In addition to diseases like HIV, cancer and PTSD, the measure also allows doctors to recommend medical pot for “other debilitating medical conditions of the same kind or class as or comparable to those enumerated, and for which a physician believes that the medical use of marijuana would likely outweigh the potential health risks for a patient.” While the 2014 measure allowed doctors to prescribe marijuana for any illness they believed it would be useful for, the new measure requires they show the illness is severe — though the wording gives physicians considerable leeway in determining which conditions would meet those criteria.

The medical pot measure in North Dakota allows doctors to recommend the drug for a number of severe medical conditions.

With the passage of Amendment 2, Florida will become the first Southern state to enact a robust medical marijuana regime. Medical marijuana is already legal in 25 other states and the District.

“Better late than never,” said Ethan Nadelmann, executive director of the drug reform group Drug Policy Alliance, in a statement. “Most states outside the South already have legal medical marijuana, but the overwhelming victory today in Florida is likely to accelerate the momentum for reform throughout the region.”

Originally published in the Washington Post.

Fighting the Opioid epidemic from the ground up: Teaching rising medical professionals how to use Naloxone

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In April of this year, Wright State University, Ohio was the staging ground for equipping healthcare students to better handle the opioid crisis. A coalition of various local activism and healthcare improvement groups assembled an event to train more than 40 aspiring professionals about how to use naloxone. The group included medical students, healthcare-related undergraduate students, pharmaceutical students, and physician assistant students.

Naloxone, the opioid antagonist used to block the effects of opioids notably in formulations such as Suboxone, has become ubiquitous in the fight against opioid overdose. Law enforcement and other emergency response forces have even begun to train to use it. Naloxone is a critical part of the opioid-dependence treatment. When bundled with buprenorphine in Suboxone, it acts to deter abuse of the opioid while ensuring that the patient does not undergo withdrawal.

The opioid crisis is critically important to healthcare providers today. The CDC reports that 91 Americans die every single day from opioid overdose, including from prescription drugs. Training health practitioners to be able to respond to this is crucial in preventing unnecessary death and getting the proper treatment to these patients.

At Acutis Diagnostics, our goal is to be a clinical tool that ensures the best possible care for the patient. Please visit our testing services page to see how our laboratory can benefit you and your patients: http://www.acutisdiagnostics.com/testing

To read more about the naloxone instruction at Wright University, please see the full article at the Sidney Daily News by following the link below.
https://goo.gl/2FQnQ8

US National toxicology program poised to add IVIVE predictive software to its retinue

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The US National Toxicology Program (NTP) has recently developed a crucial tool for clinicians and toxicologists alike called Integrated Chemical Environment (ICE). ICE is a central access point for toxicology references and for model predictions to a given substance or hazard. This tool allows robust scientific exploration of the interactions of various substances and can be used for exploratory purposes as well as predictive or confirming needs.

Notably, ICE looks to implement a clinical tool called IVIVE. In-vivo-to-in-vitro extrapolation (IVIVE) is a predictive computational tool that enables analyses of substances and interactions from the womb to after birth. This tool can be used for a variety of critical functions past the obvious ones for neonatologists and obstetricians. Linking in vitro activity to in vivo exposures and outcomes can help toxicologists and physicians understand the pathways that drugs take and improve patient outcomes for those of all ages.

The US NTP hopes to include tutorials and tools to enable people of all skill levels and backgrounds to use ICE. The tutorials should include simple answers to frequently-asked questions, guides on how to use various models, and other easily-digestible learning tools. These resources are currently under development. The US NTP predicts a 2018 launch date.

At Acutis Diagnostics, we make it a point to stay abreast of toxicology and clinical news so we can assist our patients and providers in the best ways possible. For more information about how we can help, please visit our testing services page or contact us for more information. http://www.acutisdiagnostics.com/testing

Where a patient lives might be influencing Clinician’s Opioid-prescribing decision-making

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A large-scale analytical study published by nonprofit FAIR Health earlier this month discovered correlations between the location of residence of patients, nationally and locally, and the rates at which they filed healthcare claims for opioids.

Most importantly, this study highlights that the nature of the opioid crisis is demographically quite different from state to state. The study looked at the five most-populous cities in the country: Chicago, Houston, Los Angeles, New York, and Philadelphia. It discovered the following trends about each city:

  • Out of these cities, Philadelphia has the highest proportion of claims with opioid-related diagnoses in comparison to total claims across the state.
  • Claims with opioid-related diagnoses in Los Angeles increased 31,897% from 2007 to 2016.
  • San Antonio, Texas holds only 5% of Texas’ population but is responsible for 66% of claims with opioid-related diagnoses.
  • In Illinois and Pennsylvania, males are more likely to file for claims with opioid-related diagnoses, although the gap narrows above age 50.
  • In Acutis Diagnostics’ home state of New York, the researchers found that New York City constituted 43% of the population but only 13% of the claims with opioid-related diagnoses in the state.

The researchers also found an age-related trend across the country. In suburban and rural settings, claims with opioid-related diagnoses were more concentrated among middle-aged people, whereas in cities, they were more broadly spread across all age-groups.

The study did not claim to understand why these trends have manifested, but the authors offer the following advice. All stakeholders in healthcare including patients, providers, and the government should keep a keen eye on wide trends such as these to better understand the health crisis of this era.

Here at Acutis Diagnostics, we are committed to staying at the forefront of healthcare knowledge to ensure that we can best serve the healthcare community.

Visit our Articles section to see more content we’ve published: http://www.acutisdiagnostics.com/articles

To view FAIR Health’s website, please follow this link. Information from this article was drawn from the study titled “Peeling Back the Curtain on Regional Variation in the Opioid Crisis: Spotlight on Five Key Urban Centers and Their Respective States.”

http://www.fairhealth.org

You can download the study by clicking the link to the study below.

DOWNLOAD FILE: 

PEELING_BACK_THE_CURTAIN_ON_REGIONAL_VARIATION_IN_THE_OPIOID_CRISIS_FINAL_JUNE_2017 (1).PDF

Gabapentin prescriptions rise alongside abuse, prompting questions about reclassification

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As the nation battles an opioid epidemic, clinicians across the country are forced to reconsider the abuse potential of a nerve pain medication - Gabapentin.

Gabapentin, also prescribed as Neurontin, is a nerve pain medication used to treat a variety of conditions. Most notably, it is prescribed to treat seizures and neuropathic pain. It is so commonly used in the treatment of neuropathy that it has surpassed oxycodone in volume of doses prescribed. It’s prescribed for a broad swathe of off-label uses including treatment of anxiety, insomnia, bipolar disorder, restless leg syndrome, alcoholism, migraine, hot flashes, fibromyalgia, and many other conditions.

But its frequent usage is not without its downsides. Gabapentin abuse does not get the attention it deserves from the healthcare industry. Even when prescribed and taken as directed by the company, it is possible that patients may experience ataxia, peripheral edema (swelling), drowsiness, and renal toxicity. However, patients who abuse the medication. When combined with opioids, gabapentin can provide a euphoric effect and mitigate opioid withdrawal symptoms. It can even provide a ‘boost of energy,’ as some patients and recreational users describe, or a ‘marijuana-like high’ as described by others.

Gabapentin prescriptions are not slowing down! An IMS Health study noted that prescriptions for gabapentin have increased 47% in frequency from 2011 to 2015. In 2015, the same study notes, 57 million prescriptions for gabapentin were written nationwide.

The way it’s used has been changing which may be driving the increasing volume of prescriptions. Gabapentin is not a controlled medication. The way this regulation was decided was based on the fact that it used to be use as a mono therapy, but it now is used alongside several other medications (most notably opioids!). Due to its radical shift regarding in the past decade  how it’s used, it’s prompting questions about how to classify the medication.

At Acutis Diagnostics, we aim to enrich the patient-provider experience by providing tools to build open, honest communication. Our toxicology and testing services are crucial to building transparency on the road to better health. We know that treatment is always high-priority so we provide a suite of timely services that you can learn more about at http://www.acutisdiagnostics.com/testing.

For more information about the IMS Health study regarding volume of Gabapentin prescriptions written, please visit this link.

This article was adapted from information presented in a USA Today article regarding gabapentin abuse and a Pharmacy Times article about the classification of gabapentin. Please visit the links below to access these articles.

https://amp-usatoday-com.cdn.ampproject.org/c/amp.usatoday.com/story/103293378/

http://www.pharmacytimes.com/contributor/shelby-leheny-pharmd-candidate-2017/2017/01/should-the-schedule-change-on-gabapentin